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In December 2024, the FDA issued warning letters to several companies selling peptide products online, citing compounds such as retatrutide along with semaglutide and tirzepatide being marketed under research use only disclaimers while appearing to target consumers seeking weight-loss or performance benefits

Unlike many peptides that have only injectable research data, GHK-Cu has been tested in published human clinical trials specifically as a topical application with outcomes that compared favorably against gold-standard actives

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